Spello combines its medieval features, such as winding alleys and ancient stone houses, with several remains of the Roman era, such as the town walls and the still well-preserved gates, the remains of the theatre, the amphitheatre and of the baths opened along this route.

The Villa of Mosaics in Spello, of which almost 500 square metres have been uncovered, is one of the most important archaeological discoveries made in recent years in Umbria. It offers ten rooms with beautiful mosaic floors that have extraordinary polychrome decorations, such as geometrical elements, human figures, wild and fantastic animals. The Villa of Mosaics in Spello was discovered in July 2005, just outside Spello’s walls, in the area of St. Anna, during the works for the construction of a public car park.

In this rich and active old center, the remnants of the main public, civil and religious monuments are still visible: the Curia and the Gemini Temples—overlooking the Forum—the Basilica, the Theater and the Amphitheater. The latter is positioned along the Via Flaminia, which constituted the "Cardo Maximus"—main axis, from north to south. The medieval Church of Santi Cosma e Damiano, built on a pre-existing Roman edifice along the Via Flaminia, testifies to the spreading of Christianity.