After the construction of the aqueduct by Dominican friars on a hill east of Nativitas, currently Villa de San Pedro and San Pablo Etla, the temple, convent and layout of the town were built. On the west side of the cloister there is a plaque, with the engraved legend: "Beginning and finishing year 1636". This date is considered as completion because, due to the magnitude of the building and the work done in the quarry stone, at least twenty years passed. Father Burgoa mentions that this building is due to Fathers José Calderón and Alfonso Espinoza in the year of 1620. The set consists of the atrial courtyard, temple and convent; most of them built with green quarry. The atrium has a fence with two entrances, and is equipped with gardens. The main facades of the temple and the ex-convent are integrated in a single plane oriented to the west. The cover of the temple is of two bodies. It has access with a semicircular arch and a coral window, like a niche; both flanked by intercolumnia of smooth pilasters. The auction is a pediment, with a clock on its eardrum. The interior is of a single nave covered with a barrel vault. In the presbytery is a golden cypress that houses the sculpture of the Lord of the Peñas. The convent is located on the south side of the temple. The first space it presents is the pilgrims' portal, basically a gallery composed of semicircular arches on Tuscan columns. The cloister is of two levels; the central courtyard is delimited by semicircular arcades and the corridors are domed.

At the height of Km 119 of the road No.190 this town is located, whose name means "Pueblo Nuevo" in Nahuatl and that, formerly, was called Yosocahui, which in Mixtec means "El Llano Nuevo". Here you can admire the Temple and Ex-convent of Santo Domingo, a complex that, at the time, was the second in importance of the Dominican order in the Oaxaca region. Nowadays, it constitutes one of the most outstanding examples of the novo-Hispanic architecture of the 16th century. The construction was erected on a huge pre-Hispanic platform and although some modifications were made in the 18th century, it retains in its place the original paintings and sculptures, among which the main 16th-century altarpiece elaborated by the Sevillian painter Andrés de la Concha.

This population is located 23 km from the previous point by the deviation to Tlaxiaco, on the highway No. 190 in its section Oaxaca-Mexico. The Dominicans settled here in 1541, starting shortly after the construction of a fabulous religious complex, with a magnificent open chapel that is one of the most important works of the sixteenth century in New Spain. It should be noted that this chapel had two choirs, one for singers and one for musicians. At the time, the chapel was decorated with an altarpiece made by the painters Andrés de la Concha and Andrés Pereyns of whom some works are preserved inside the temple.

This beautiful Dominican complex, completed in 1576 as it appears on its façade, consists of a temple, a cloister, an open chapel and an atrium, forming one of the most peculiar examples of 16th-century Novo-Hispanic art and architecture. Its decoration, mainly that of the exterior of the temple, presents very original features, in addition to magnificent sculptures, among which the ensemble formed by San Juan Bautista, flanked by San Pedro and the Apostle Santiago and a series of shell-shaped niches, stands out. Great rosettes, medallions and symbols of passion.