Also simply known as Orta, it is part of the club of the most charming villages in Italy. From the Medieval age to the 18th century, Orta was the chief town of an independent association of cities called "Comunità della Riviera", well defended by the natural configuration of the site. The town centre is characterized by narrow alleys, mostly converging into the beautiful Piazza Motta, seat of the City Hall and overlooking the lake.

The isle is the only one in the lake of Orta and belongs to the municipality of Orta San Giulio. Probably inhabited since the Iron age, the isle has been considered a strategic site since the 6th century and thus surrounded by defensive walls. After having been a stage for the rivalry between the Sacred Roman Empire and the Lombard kingdom in the 10th century, the whole lake district was ceased to the bishops of Novara, who reconstructed on the island the cathedral of San Giulio in a Romanesque style. In 1841, the medieval castle was demolished to make room to a Seminary, designed by architect Ferdinando Caronesi.