Ponte Fabricio, also known as the Bridge of the Four Heads, is the oldest bridge in Rome that still preserves its original structure. It was built in 62 BC. On Tiber Island, during the Roman era, stood the Temple of Aesculapius. According to legend, in 293 BC, a severe plague broke out in Rome, prompting the Senate to build a temple dedicated to the Greek god of medicine, Asclepius, who was known by his Latin name Aesculapius. Asclepius (Greek) or Aesculapius (Latin) is a figure from Greek and Roman mythology. He became the god of medicine, deeply venerated by the people for his kindness toward the sick.

From Etta Ristorante (first stop), located in Piazza in Piscinula, you enter an area whose name comes from the presence of ancient Roman thermal baths with pools (“piscinula” is a diminutive form). In the past, Rome was full of such baths, many of which gave their names to various neighborhoods. This is the only square where the name remained. Overlooking this magical square, with its medieval charm, are the 15th-century Mattei Houses, built by incorporating 14th-century buildings that already belonged to the Mattei family.

From Piazza in Piscinula, you can reach the House of Dante, which has become, in over a hundred years of history, one of the most prestigious and active Dante research centers in Italy and abroad.

You then arrive at Vicolo del Moro, a chameleon-like street, with the ability to transform between day and night. The walk is enriched by local shops and artisans. At night, the area becomes one of the most lively parts of Rome’s nightlife. After just a few steps, you're embraced by the aroma of freshly baked bread from La Renella Bakery, one of the oldest in Rome.

You finally arrive at Piazza di Santa Maria in Trastevere, the ancient heart of Trastevere. The square is dominated by the Basilica of Santa Maria in Trastevere, from which it takes its name. It was founded in 217 AD by Pope Callixtus. The 13th-century mosaics on the church’s façade are truly spectacular. The square is also home to a fountain considered the oldest in Rome, as it was built in the same place where a fountain already stood during the time of Emperor Augustus. Surrounding the square, to the right of the basilica, is the House of the Canons of Santa Maria; to the left, the Palazzo San Callisto, the Palazzo Cavalieri (built in the 16th century), and the 17th-century Palazzo Pizzirani.